IPNO's Casework Program provides legal and investigative assistance to wrongfully convicted prisoners serving life sentences in Louisiana and more recently, Mississippi.

The Exoneree Advocacy Program, brings the voices of the wrongfully convicted to a wider audience and positions exonerees as advocates for policy reform on a local and regional level, as well as supporting them through their transition to life in the free world.

The Outreach and Reform Program uses individual exonerations as catalysts for dialog with policy makers, who in the wake of an exoneration are motivated to take stock of their practices and identify what went wrong. This program also promotes the work of IPNO in prisons to ensure prisoners have access to IPNO's services, and in educational settings such as law schools to encourage young people to become forces for change in this area of law.